Posts tagged ALK Mutation
A Compound L1196M/G1202R ALK Mutation in a Patient with ALK-Positive Lung Cancer with Acquired Resistance to Brigatinib Also Confers Primary Resistance to Lorlatinib
A Compound L1196M/G1202R ALK Mutation in a Patient with ALK-Positive Lung Cancer with Acquired Resistance to Brigatinib Also Confers Primary Resistance to Lorlatinib

We report here the case of a 70-year-old patient with ALK-positive NSCLC treated with crizotinib as part of the ALTA-1L trial.4 The patient relapsed after a partial response. After crizotinib failure, the patient was crossed over to brigatinib, which led to a second partial response lasting 9 months. After progression, the patient was shifted to lorlatinib but the clinical conditions worsened and the patient died. READ ARTICLE

Journal of Thoracic Oncology DOI:10.1016/j.jtho.2019.06.028

Authors: Geeta G. Sharma, Diego Cortinovis, Francesco Agustoni, Giulia Arosio, Matteo Villa, Nicoletta Cordani, Paolo Bidoli, William H. Bisson, Fabio Pagni, Rocco Piazza, Carlo Gambacorti-Passerini, Luca Mologni

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EditorialKirk SmithL1196M, G1202R, ALK Mutation, ALK-Positive Lung Cancer, Acquired Resistance, Brigatinib, Primary Resistance, Lorlatinib