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Grapefruit & TKIs
A Review: Interview with Dr. Lin, Does Grapefruit Interfere with TKIs? The interview with Dr. Lin covered topics that we should know about with regards to cytochrome P450 and its significance in processing TKI* medication. Cytochrome P450 is part of a system important in metabolizing medicine in the liver. Cytochromes metabolize oily (fat-soluble) chemicals so they…
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How do ALK TKIs affect pregnancy?
Studies on ALK TKIs* and Pregnancy In 2016, there was a study reported by Dr. Ibiayi et. al. (Dr. Shaw’s group) on patients who were pregnant or had just given birth to a child while diagnosed with NSCLC (non-small cell lung cancer) between 2009 and 2015. They identified 2422 women with lung cancer of whom…
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Biomarker Testing, explained
Ever wondered what biomarker testing really refers to and what it means for your treatment options? Read on for a simplified explanation of how biomarkers can drive cancer, how testing is done, and how they can affect treatment decisions. Bonus section: an unusual case study where a patient achieved partial remission by re-using Brigatinib after…
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What exactly is ALK-positive lung cancer?
Find out more about the history of ALK fusion with an emphasis on early discovery, diagnostic methods, and the development of the first targeted ALK inhibitors. ALK Lung Cancer 101 These links provide a good general explanation of what ALK-positive lung cancer means for a newly-diagnosed patient. https://lcfamerica.org/lung-cancer-info/types-lung-cancer/alk-positive-lung-cancer https://www.webmd.com/lung-cancer/faq-stage-four-lung-cancer-with-alk#1 How did it all start?…
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MET and TP 53: How they relate to ALK lung cancer
MET Amplification MET is a receptor tyrosine kinase that participates in the hepatocyte growth factor (HGF)-mediated signaling pathway. This protein is anchored to the cell wall to pass information from the outside the cell to the inside of the cell. Normally, the receptor is activated by binding to HGF. This binding leads to phosphorylation (adding…