Posts tagged high glycolysis
2-Deoxy-D-Glucose Sensitizes Non-Small Cell Lung Cancer with EML4-ALK Fusion to Crizotinib via Suppression of HK2 Through AKT/mTOR Passway
2-Deoxy-D-Glucose Sensitizes Non-Small Cell Lung Cancer with EML4-ALK Fusion to Crizotinib via Suppression of HK2 Through AKT/mTOR Passway

Background: ALK-positive NSCLC cells (ALK+ NSCLC) present high glycolysis. Targeting cancer cell metabolism with the glycolysis inhibitor, 2-deoxyglucose (2DG), is a viable strategy that sensitizes the fist-line ALK-TKI crizotinib; but the effects of combination of 2DG and Crizotinib on ALK+ NSCLC cells and the mechanism of action are unknown. Conclusion: This study demonstrated that 2DG would be a promising drugs to sensitize crizotinib via suppressing HK2 expression to inhibit the activity of AKT/mTOR signaling pathway induced by ALK phosphorylation. READ ARTICLE

Journal of Thoracic Oncology DOI:10.1016/j.jtho.2019.08.1820

Authors: EML4-ALK, crizotinib, high glycolysis

Read More
Conference PaperKirk SmithEML4-ALK, crizotinib, high glycolysis