Immunotherapy for ALK-Rearranged Non-Small Cell Lung Cancer: Challenges Inform Promising Approaches

Review Paper describing the mechanisms of ALK aberrations in non-small cell lung cancer by which an immunosuppressed tumor microenvironment is created, leading to host immune evasion. Reports pre-clinical and clinical studies evaluating novel immunotherapeutic approaches and describes the promises and challenges of incorporating immune-based treatments for ALK-rearranged non-small cell lung cancer. READ ARTICLE

Cancers DOI: 10.3390/cancers13061476

Authors: Kamya Sankar, Sunitha Nagrath, Nithya Ramnath

Review PaperKirk SmithMarch 1, 2021ALK, ALK-rearrangements, NSCLC, TKI, immune evasion, immunotherapy, cancer vaccine