Cancer is closely related to age, and the incidence of cancer increases with age. However, there are few studies on the relationship between age and clinical characteristics of lung cancer. We collected all the consecutive lung cancer cases from 2012 to 2017 in our hospital and divided them into 6 groups according to their ages: ≤ 40 y/o, 41∼ 50 y/o, 51∼ 60 y/o, 61∼ 70 y/o, 71∼ 80 y/o and > 80 y/o. There were more non-smokers (p< 0.01), stage IV (p< 0.01) and anaplastic lymphoma kinase (ALK) fusion (p< 0.01) patients but less stage I patients in ≤ 40 y/o group compared with other age groups. It seemed that older patients were more likely had co-exist driver gene mutations (p=0.04). There are some differences in clinical characteristics and prognosis among different age groups. The reasons behind the phenomenon are largely unclear. The age should be taken into account when we develop clinical trials...... READ ARTICLE
Cancer Management and Research DOI:10.2147/CMAR.S240318
Authors: Chen X, Han X, Zhou H, Liang Y, Huang Z, Li S, Lin Y, Huang X, Wu J, Su W, Lai Z and Yang Z
