Our study aimed to correlate the percentage of ALK rearrangement found as a predictor of response in NSCLC ALK-positive treatment. Designed a retrospective study with NSCLC ALK rearrangement patients in a peripheral Hospital from the last six years. Collected demographic data, histology, disease stage, the percentage of ALK rearrangement detected by FISH, lines of treatment, the response rate (RR) evaluated by RECIST 1.1 criteria, the progression-free survival (PFS) and the overall survival (OS) in patients under ALK inhibitors. Results are presented as medians and range for non-normally distributed continuous variables and as number/total for categorical data. Statistical analysis was performed using U-Mann-Whitney test, considering a significance level of 5%. Besides our negative results with the the percentage of ALK rearrangement, we found in our sample an improvement in the RR, PFS and OS in patients that made in first line, ALK inhibitors rather than platinum-based chemotherapy, ..... READ ARTICLE
Journal of Thoracic Oncology DOI:10.1016/j.jtho.2019.08.2397
Authors: M. Oliveira, R. Natal, J. Costa, R. Gomes, A. Amaral, L. Ferreira