Diagnostic accuracy of PCR for detecting ALK gene rearrangement in NSCLC patients: A systematic review and meta-analysis

NGS evaluation with the Oncomine Solid Tumour Fusion transcript kit and RT-PCR proved to have high sensitivity and specificity, advocating their use in routine practice. For maximal sensitivity and specificity, ALK status should be assessed by using two techniques and a third one in discordant cases. We therefore propose a customizable testing algorithm. These findings significantly influence existing testing paradigms and have clear clinical and economic impact. READ ARTICLE

Journal of Thoracic Oncology DOI: 10.1016/j.jtho.2017.11.117

Authors: Igor Letovanec, Stephen Finn, Panagiota Zygoura, Paul Smyth, Alex Soltermann, Lukas Bubendorf, Ernst-Jan Speel, Antonio Marchetti, Daisuke Nonaka, Kim Monkhorst, Henrik Hager, Miguel Martorell, Aleksandra Sejda, Richard Cheney, Javier Hernandez-Losa, Eric Verbeken, Walter Weder, Spasenija Savic, Alessia Di Lorito, Atilio Navarro, Enriqueta Felip, Arne Warth, Paul Baas, Peter Meldgaard, Fiona Blackhall, Anne-Marie Dingemans, Hendrik Dienemann, Rafal Dziadziuszko, Johan Vansteenkiste, Cathal O'Brien, Thomas Geiger, Jon Sherlock, Jeoffrey Schageman, Urania Dafni, Roswitha Kammler, Keith Kerr, Erik Thunnissen, Rolf Stahel, Solange Peters, Rolf A. Stahel, Rafael Rosell, Fiona Blackhall, Urania Dafni, Keith M. Kerr, Miguel Ángel Molina, Lukas Bubendorf, Walter Weder, Erik Thunnissen, Solange Peters, Stephen Finn, Anita Hiltbrunner, Roswitha Kammler, Thomas Geiger, Nesa Marti, Urania Dafni, Zoi Tsourti, Varvara Polydoropoulou, Panagiota Zygoura, Stephen Finn, Paul Smyth, Cathal O’Brien, Steven Gray, Walter Weder, Alex Soltermann, Isabelle Opitz, Alessandra Curioni, Lukas Bubendorf, Spasenija Savic, Didier Lardinois, Anne-Marie Dingemans, Ernst-Jan M. Speel, Andrea Ruland, Antonio Marchetti, Alessia Di Lorito, Graziano De Luca, Sara Malatesta, Fiona Blackhall, Daisuke Nonaka, Anne Marie Quinn, Lynsey Franklin, Wojciech Biernat, Ania Wrona, Witold Rzyman, Jacek Jassem, Peter Meldgaard, Henrik Hager, Line B. Madsen, Carlos Camps, Miguel Martorell, Eloisa Jantus-Lewintre, Ricardo Guijarro, Keith M. Kerr, Marianne Nicolson, David A.J. Stevenson, William Mathieson, Paul Baas, Jeroen de Jong, Kim Monkhorst, Erik Thunnissen, Egbert Smit, Coralien van Setten, Joop de Langen, Enriqueta Felip, Javier Hernandez-Losa, Irene Sansano, Richard Cheney, Mary Beth Pine, Mary Reid, Elizabeth Taylor, Kristiaan Nackaerts, Christophe Dooms, Els Wauters, Sara Van Der Borght, Hendrik Dienemann, Thomas Muley, Arne Warth

Real-World OutcomesKirk SmithMarch 1, 2018ALK, RT-PCR, non-small cell lung cancer (NSCLC), next-generation sequencing (NGS)