Management of Central Nervous System Metastases in Patients With Advanced Anaplastic Lymphoma Kinase-Rearranged Non–Small-Cell Lung Cancer During Crizotinib Treatment

"Background: Central nervous system (CNS) progression is a common manifestation of acquired resistance to crizotinib in anaplastic lymphoma kinase (ALK)-rearranged non–small-cell lung cancer (NSCLC). However, an optimal tailored treatment approach has not been established in patients with CNS failure during crizotinib treatment. Conclusion: Although CBPD is an option in patients with isolated CNS progression during crizotinib treatment, sequential treatment with a second ALK TKI, particularly brigatinib, might be preferable. The newly approved TKI, brigatinib, showed promise in the control of brain metastases, even without radiotherapy. READ ARTICLE

Clinical Lung Cancer DOI:10.1016/j.cllc.2019.06.013

Authors: Yiming Zhao, Bo Zhang, Shuyuan Wang, Rong Qiao, Jianlin Xu, Lele Zhang, Yanwei Zhang, Baohui Han"

Real-World OutcomesKirk SmithNovember 1, 2019Brain metastases, Brigatinib, Crizotinib, Next-generation ALK TKI, Progression