Posts tagged Molecular features
Unique molecular features and clinical outcomes in young patients with non-small cell lung cancer harboring ALK fusion genes
Unique molecular features and clinical outcomes in young patients with non-small cell lung cancer harboring ALK fusion genes

Purpose: This study aimed to determine the molecular features and clinical outcomes of young patients with non-small cell lung cancer (NSCLC) harboring ALK fusion genes. Conclusion: Unique genetic characteristics were found in ALK-rearranged NSCLC patients with early disease onset, and these patients responded better to crizotinib and had longer PFS compared to patients with later disease onset. However, patients with concomitant TP53 mutations may not have a significant response to treatment. READ ARTICLE

Journal of Cancer Research and Clinical Oncology. DOI: 10.1007/s00432-019-03116-6

Authors: Panwen Tian, Yujie Liu, Hao Zeng, Yuan Tang, Analyn Lizaso, Junyi Ye, Lin Shao & Yalun Li

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Case StudyKirk SmithYoung patients, Non-small cell lung cancer, Molecular features, ALK fusion genes