Here, we report a novel melanoregulin (MREG)-ALK fusion, which is sensitive to crizotinib, in a patient with lung adenocarcinoma and brain metastasis. A 65-year-old nonsmoking Chinese woman was admitted to the local hospital with cough since 2 months. She had no fever, expectoration, or headache. Computed tomography scans of her chest reported an irregular nodular mass in the left main bronchial wall and the left lingual lobe, with a narrowing of the left lower lobe bronchi, Meanwhile, cranial computed tomography and magnetic resonance imaging revealed a space-occupying lesion in the frontal lobe, accompanied by bone destruction, which was considered a metastatic tumor. A biopsy through fiberoptic bronchoscopy was performed, and pathologic analysis reported a poorly differentiated lung adenocarcinoma with mucin production in cytoplasm. Formalin-fixed, paraffin-embedded specimens from bronchoscopy biopsy were sent for genomic testing by next-generation sequencing. Results revealed that ..... READ ARTICLE
Journal of Thoracic Oncology DOI:10.1016/j.jtho.2019.11.019
Authors: Leiming Wang, Shuyang Yao, Lianghong Teng, Weiwei Zhang, Li Chen