Background: High concordance has been observed between Ventana D5F3 ALK immunohistochemistry (IHC) and fluorescence in-situ hybridization (FISH) in lung adenocarcinoma (LADC). However, whether a similar conclusion can be applied to lung squamous-cell carcinoma (LSCC) has remained unclear. We therefore evaluated the ALK (anaplastic lymphoma kinase) status and the therapeutic effect of an ALK tyrosine kinase inhibitor (TKI) in IHC- or FISH-positive LSCC. Conclusions: The positive concordance rate of ALK IHC and FISH in LSCC is far less than that reported for LADC. Therefore, ALK IHC detection in LSCC cannot be used as a diagnostic method for ALK rearrangement. READ ARTICLE
Lung Cancer
DOI:10.1016/j.lungcan.2019.02.015
Authors: Haiyue Wang, Leina Sun,Yaxiong Sang, Xin Yang, Guangming Tian, Ziping Wang, Jian Fang, Wei Sun, Lixin Zhou, Ling Jia, Ming-Sound Tsao, Huaiyin Shi, Dongmei Lin