Background: Anaplastic Lymphoma Kinase (ALK) re arrangement is observed in about 3% to
7% lung Adenocarcinoma (ADC). With the development of Next-Generation Sequencing (NGS)
technology, more novel ALK fusions have been discovered, which can provide patients more
opportunities to receive target therapies and achieve clinical effects.
Case Report: A case of an invasive lung ADC patient with micropapillary and solid patterns
harboring a novel ALK fusion (ME1-ALK) was reported. Then, thoracoscopic resection of right upper
lung and cautery division of pleural adhesions were performed with general anesthesia. Considering
that solid and micropapillary components accounted for 50%, nedaplatin plus pemetrexed were
administrated for 4 cycles after operation with the patient's consent. The patient had no recurrence
and the Disease Free Survival (DFS) was 10 months by May 17th, 2021.
Conclusion: This case highlights that NGS profiling can identify more novel fusions and help solid/
micropapillary-lung ADC patients find more opportunities to receive target therapies if the patient
recurrence. READ ARTICLE
Annuals of Clinical Case Report DOI:ISSN: 2474-1655
Authors: Wang X, Zhang C, Shang Z, Yang D, Li M, Luo N, Wu Y