Switching to an alternative ALK-inhibitor after alectinib-induced pneumonitis resulted in resolution of this adverse event

This report adds to the available literature and demonstrates that utilizing an alternative ALK-inhibitor may be a potential management strategy for drug-induced ILD/pneumonitis that allows patients to continue to receive these effective therapies. READ ARTICLE

Current Problems in Cancer: Case Reports DOI: 10.1016/j.cpccr.2020.100023

Authors: Evan Bryson, Suresh Ramalingam, Tyler Beardslee

Case StudyKirk SmithDecember 1, 2020Interstitial lung disease, Pneumonitis, Drug-induced pneumonitis, ALK-inhibitor induced pneumonitis

Interstitial Lung Disease Onset and Its Risk Factors in Japanese Patients With ALK-Positive NSCLC After Treatment With Crizotinib

The study objective was to determine the incidence and characteristics of drug-induced interstitial lung disease (ILD) associated with an orally available small-molecule tyrosine kinase inhibitor, crizotinib, in a real-world clinical setting.
We concluded that crizotinib therapy should be applied to the NSCLC patients with any of above risk factors under a cautious monitoring for ILD occurrence, and clinicians should pay attention to the risks of severe ILD. READ ARTICLE

Journal of Thoracic Oncology DOI:10.1016/j.jtho.2018.11.022

Authors: Akihiko Gemma, Masahiko Kusumoto, Yasuyuki Kurihara, Noriyuki Masuda, Shigeo Banno, Yutaka Endo, Hiroyuki Houzawa, Naomi Ueno, Emiko Ohki, Akinobu Yoshimura

Real-World OutcomesKirk SmithApril 1, 2019Crizotinib, Tyrosine kinase inhibitor (TKI), Interstitial lung disease, Anaplastic lymphoma kinase-positive, NSCLC