Highlights: • First two cases of ALK-rearranged LUAD that transformed to high-grade LCNEC after ALK-TKI treatment. • Development of on-target ALK G1202R mutation, showing unique dual mechanisms of resistance in both cases. • Different RB1 status in both cases, with worse outcome in the case with RB1 loss. READ ARTICLE
Lung Cancer DOI:10.1016/j.lungcan.2020.06.005
Authors: Aline F. Fares, Benjamin H. Lok, Tong Zhang, Michael Cabanero, Sally C. M. Lau, Tracy Stockley, Devalben Patel, Penelope A. Bradbury, Adrian Sacher, Kazuhiro Yasufuku, Barbara A. Morash, Peter J. B. Sabatini, Lananhn N. Nguyen, Natasha B. Leighl, Ming-Sound Tsao, Frances A. Shepherd, Geoffrey Liu, Sebastiao N. Martins-Filho, Prodipto Pal