Bio-Nanocarriers for Lung Cancer Management: Befriending the Barriers

Lung cancer is a complex thoracic malignancy developing consequential to aberrations in a myriad of molecular and biomolecular signaling pathways. It is one of the most lethal forms of cancers accounting to almost 1.8 million new annual incidences, bearing overall mortality to incidence ratio of 0.87. The dismal prognostic scenario at advanced stages of the disease and metastatic/resistant tumor cell populations stresses the requisite of advanced translational interdisciplinary interventions such as bionanotechnology. This review article deliberates insights and apprehensions on the recent prologue of nanobioengineering and bionanotechnology as an approach for the clinical management of lung cancer. The role of nanobioengineered (bio-nano) tools like bio-nanocarriers and nanobiodevices in secondary prophylaxis, diagnosis, therapeutics, and theranostics for lung cancer management has been discussed. Bioengineered, bioinspired, and biomimetic bio-nanotools of considerate translational va..... READ ARTICLE

Nanomicro Letters DOI:10.1007/s40820-021-00630-6

Authors: Shruti Rawal and Mayur Patel

Review Paper, group5Kirk SmithJune 12, 2021Biomimetic nanoparticles, Exosomes, Circulating tumor cells, Mesenchymal stem cells, Theranostics

EML4-ALK TRANSLOCATION IDENTIFICATION IN RNA EXOSOMAL CARGO (EXOALK) IN NSCLC PATIENTS: A NOVEL ROLE FOR LIQUID BIOPSY

The introduction of druggable targets has significantly improved the outcomes of non-small cell lung cancer patients (NSCLC). EML4-ALK translocation represents 4–6% of the druggable alterations in NSCLC. With the approval of Crizotinib, first discovered drug for the EML4-ALK translocation, on first line treatment for patients with detected mutation meant a complete change on the treatment landscape. The current standard method for EML4-ALK identification is immunohistochemistry or FISH in a tumor biopsy. However, a big number of NSCLC patients have not tissue available for analysis and others are not suitable for biopsy due to their physical condition or the location of the tumor. Liquid biopsy seems the best alternative for identification in these patients that have no tissue available. Circulating free RNA has not been validated for the identification of this mutation. As a complementary tool, exosomes might represent a good tool for predictive biomarkers study, and due to their stab..... READ ARTICLE

Translational Cancer Research DOI:10.21037/tcr.2018.11.35

Authors: Reclusa, P. (Pablo), Laes, J.F. (Jean-François), Malapelle, U. (Umberto), Valentino, A. (Anna), Rocco, D. (Danilo), Gil-Bazo, I. (Ignacio), Rolfo, C. (Christian)

Pre-ClinicalKirk SmithJanuary 1, 2019Exosomes, Liquid biopsy, ALK translocation, Non-small cell lung cancer (NSCLC), Biomarkers