![Discovery of 3,6-diaryl-1H-pyrazolo[3,4-b]pyridines as potent anaplastic lymphoma kinase (ALK) inhibitors](https://images.squarespace-cdn.com/content/v1/5b6cc61596d4557796b187fe/1639062347000-15K9XASMF8EWX742HB9Q/ALK_Pre-Clinical.jpg)
A new series of 3,6-diaryl-1H-pyrazolo[3,4-b]pyridine compounds have been discovered as potent anaplastic lymphoma kinase (ALK) inhibitors. The 4-hydroxyphenyl in the 6-position of 1H-pyrazolo[3,4-b]pyridine were crucial and a fluorine atom substitution could give promising inhibitory activity. The IC50 of compound 9v against ALK was up to 1.58 nM and a binding mechanism was proposed. READ ARTICLE
Bioorganic & Medicinal Chemistry Letters DOI:10.1016/j.bmcl.2019.01.037
Authors: Changwei Chen, Peichen Pan, Ziyang Deng, Dahai Wang, Qifan Wu, Lei Xu, Tingjun Hou, Sunliang Cui