Posts tagged ADENOCARCINOMA
Long-term response to Crizotinib in a 17-year-old boy with naive alk-positive Non-Small Cell Lung Cancer

Lung cancer is the leading cause of cancer-related death. NSCLC accounts for 80-90% of cases. In younger patients, adenocarcinoma is the most frequent histotype and 3-7% expresses the rearrange-ment of ALK oncogene, sensitive to TKIs. Crizotinib is the first ALK inhibitor approved by FDA. We present the case of a 17-year-old male with metastatic naïve ALK-positive adenocarcinoma, treated with crizotinib. He received crizotinib and obtained a prolonged response with PFS of 33 months. Crizotinib can be extremely effective in adolescent with naïve ALK-positive NSCLC but it hardly penetrates blood-brain barrier. Resistance mechanisms will be investigated for a better man-agement. READ ARTICLE

Authorea DOI:10.22541/au.160620307.75734495/v1

Authors: megaro g, Miele E, Spinelli GP, et al.

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