Aim of this study was to analyse the frequency of epidermal growth factor receptor (EGFR) mutations, ALK and ROS1 rearrangements and their association with age and gender in non-small cell lung cancer reported from a tertiary care center in South India. The study found EGFR mutations are more common than ALK and ROS1 rearrangements. They are more common in females. Patients less than 36 years have reduced frequency of EGFR mutations. Exon 19 deletion and L858R are most common and are more prevalent in lung adenocarcinomas. Rare EGFR mutations are seen in patients aged more than 50 years. READ ARTICLE
Cancer Reports DOI:10.1002/cnr2.1288
Authors: Anil Tarigopula, Gayathri Ramasubban, Vani Chandrashekar, Perumal Govindasami, hitra Chandran
