Background: Although smoking is a primary cause of lung cancer, females are overrepresented among never-smokers with the disease. The mutational landscape of adenocarcinoma in never-smoking females has been extensively profiled; however, there is little knowledge about genomic alterations in non-adenocarcinoma non–small-cell lung cancer (NA-NSCLC). In the study, we reviewed the status of oncogenic drivers of NA-NSCLC in these populations... Conclusion: Female never-smokers with NA-NSCLC in this study had a high frequency of currently known or potentially actionable oncogenic alterations and could benefit from targeted therapy. Our study also provides evidence for the recommendation of molecular analysis in never-smoking female SQCC. READ ARTICLE
Clinical Lung Cancer DOI:10.1016/j.cllc.2020.02.005
Authors: Yiming Zhao, Yu Dong, Ruiying Zhao, Bo Zhang, Shuyuan Wang, Lele Zhang, Minjuan Hu, Qingnan He, Wei Zhang, Baohui Han
