Impact of STAT1 polymorphisms on crizotinib-induced hepatotoxicity in ALK-positive non-small cell lung cancer patients

Polymorphism of rs10208033 is a potential biomarker for predicting crizotinib-induced hepatotoxicity. These results suggest that STAT1 plays an important role in crizotinib-induced hepatotoxicity. Further studies are needed to confirm our finding and understand the underlying mechanisms. READ ARTICLE

Journal of Cancer Research and Clinical Oncology DOI:10.1007/s00432-020-03476-4

Authors: Xin, S., Fang, W., Li, J. et al.