Study Proposes proposes PI3Kβ as a novel regulator of ALKi resistance in ALK-rearranged lung cancer cells, showing efficacy even in aggressive TP53 mutant and mesenchymal cells. Given that multiple salvage signals are activated upon resistance to ALKi, the co-targeting of PI3Kβ may provide a promising therapy option as PI3Kβ acts as a common effector of multiple salvage pathways, including EGFR, autophagy and GPCRs. Importantly, we found that co-targeting of PI3Kβ showed reduced toxicity in normal lung epithelial cells when compared with co-targeting of EGFR, possibly providing for a relatively safe clinical direction to treat ALK-rearranged tumors. READ ARTICLE
BioRxIV DOI:10.1101/2021.03.18.435801
Authors: Sarang S. Talwelkar, Mikko I. Mäyränpää, Julia Schüler, Nora Linnavirta, Annabrita Hemmes, Simone Adinolfi, Matti Kankainen, Wolfgang Sommergruber, Anna-Liisa Levonen, Jari Räsänen, Aija Knuuttila, Emmy W. Verschuren, Krister Wennerberg
