Background: The aim of this study was to determine the demographic prole ofdriver gene alterations, especially low-frequency gene alterations in Chinesepatients with non-small cell lung cancer (NSCLC).Methods: A total of 7395 Chinese patients with NSCLC were enrolled in thestudy. Next-generation sequencing (NGS) was performed on formalin-xedparafn-embedded specimens collected via either surgical resection or biopsy.Results: The frequent genomic alteration s found in the study were EGFR muta-tions (51.7%), KRAS mutations (13.1%), MET alterations (5.6%; 3.2% copy num-ber gains and 0.5% exon 14 skipping mutation), HER2 alterations (7.0%; 2.0%copy number gains and 5.4% mutations), ALK alterations (7.2%; 3.9%rearrangements), RET rearrangements (1.4%), ROS1 rearrangements (0.9%), andNTRK rearrangements (0.6%). The EGFR mutation rate was found to be signi-cantly higher in women than in men (69.1% vs. 38.5%, P < 0.001), while theKRAS mutation (17.5% vs. 7.3%, P < 0.001) and MET alteration ..... READ ARTICLE
Thoracic Cancer DOI:10.1111/1759-7714.13757
Authors: Xiaoyan Si, Ruili Pan, Shaohua Ma, Lin Li, Li Liang, Ping Zhang, Yuping Chu, Hanping Wang, Mengzhao Wang, Xiaotong Zhang, Li Zhang
