New promising circulating RNA biomarkers for early diagnosis of lung adenocarcinoma

Clinical practice relies in the use of specific biological parameters which can be correlated with the onset, establishment, development and therapeutic response of diseases. Biomarkers have becoming even a more relevant research topic in clinics since the foundation of the precision medicine initiatives worldwide. The choice of specific biomarkers is dependent on their sensitivity and specificity for a particular disease, but also on technical aspects related with their collection protocol, stability and detection from biological samples. In clinical oncology, early diagnosis biomarkers are very important for the prevention of the incidence of cancers, but also for the establishment of proper therapeutic strategies... Despite of the lack of knowledge about the subjacent molecular mechanisms involved in the secretion of circRNAs by cancer cells, there is increased evidence about their use as molecular circulating biomarkers for the stratification and prognosis of tumors, as illustrate..... READ ARTICLE

Annals of Translational Medicine
DOI:10.21037/atm.2019.05.70

Authors: Francisco J. Enguita