Lung cancer family history and exposure to occupational/domestic coal combustion contribute to variations in clinicopathologic features and gene fusion patterns in non-small cell lung cancer

Background: Both genetic and environmental factors contribute to the development of cancer and its mutant spectrum. Lung cancer has familial aggregation. Lung cancer caused by non-tobacco factors has unique pathological and molecular characteristics. The interaction between genetic lung cancer susceptibility and carcinogens from coal burning remains complex and understudied. Conclusion: FLC and exposure to coal combustion have an important impact on the clinicopathological characteristics and gene fusion mode of NSCLC, particularly in cases of higher levels of carcinogens, and genetic susceptibility has a greater impact. Our findings may help evaluate the effect of FLC and coal exposure on the pathogenesis of lung cancer. READ ARTICLE

Thoracic Cancer
DOI:10.1111/1759-7714.12987

Authors: Ying Chen, Guangjian Li, Yujie Lei, Kaiyun Yang, Huatao Niu, Jie Zhao, Rui He, Huanqi Ning, Qiubo Huang, Qinghua Zhou, Yunchao Huang