A 53-year-old African American man who had never smoked was initially diagnosed with clinical stage cT2pN3 (contralateral mediastinal node) M0, IIIB EML4-anaplastic lymphoma kinase translocation–positive (ALK+) adenocarcinoma of the right lung. He was treated with concurrent chemotherapy using pemetrexed/carboplatin and 60 Gy of radiation to the lung and mediastinum. The patient tolerated these treatments well with complete response in the chest, but he developed biopsy-proven solitary metastatic recurrence in the liver 1 year later. He underwent stereotactic radiation therapy with 30 Gy in 3 fractions, followed by crizotinib at this time. READ ARTICLE
Practical Radiation Oncology DOI:10.1016/j.prro.2018.11.002
Authors: William R. Grubb, Mitchell Machtay, Afshin Dowlati, Tithi Biswas
