What is YAP and its significance for ALK-positive cancer

In recent years, a signal pathway called HIPPO, which is important in angiogenesis (blood vessel growth), has become important for the ALK cancer realm. There has been accumulating evidence that a protein called YAP (Yes Associated Protein-1) can prevent TKI-resistant cells from developing resistance in vitro and in vivo (in laboratory experiments and in cell experiments). This pathway is very important as there is evidence that it is very well-preserved in evolution - there are homologs to humans in Drosophila (fruit flies).

Research, Clinical TrialsKirk SmithMarch 22, 2022YAP

LUNGevity Partners with ALK Positive to Award $1.5 Million in Lung Cancer Research Grants

WASHINGTON, DC (January 27, 2022) — LUNGevity Foundation is partnering for the third time with the patient-led registered nonprofit organization ALK Positive to support the ALK-Positive Lung Cancer Research Award Program. This year, the patient oncogene group will potentially fund research projects totaling up to $1.5 million over two years—their largest funding to date. The ultimate goal of the research is to transform ALK-positive lung cancer into a chronic or curable condition.

ResearchKirk SmithJanuary 27, 2022Research, Research Grants, Lungevity

STRONGER TOGETHER: The Latest From ALK Positive, Inc.

Here are a few of the latest highlights of what our nonprofit has been up to since the last update:

• A big, heartfelt thank you to everyone who has donated or fundraised for ALK Positive, Inc. in 2021. Our Lung Cancer Awareness Month and End-of-Year Giving campaigns raised almost $1.5M in November and December thanks to the enthusiastic participation of members from all over the world and the generous matching donations of a number of committed donors.

ResearchKirk SmithJanuary 19, 2022ALK Positive Inc, Judith Tam, Medical Committee

$7.6M Gift Launches New Lung Cancer Research Initiative at University of Michigan's Rogel Cancer Center

HUGE Announcement from the University of Michigan's Rogel Cancer Center - this $7.6 million gift from from Judith L. Tam and the Richard Tam Foundation may be the largest made to-date specifically for ALK positive research. #ResearchSavesLives

ResearchKirk SmithJanuary 19, 2022research, Judith Tam