A new ALK inhibitor starts its clinical trials this month! TPX-0131 is an TKI ALK inhibitor designed to overcome multiple ALK resistance mutations. This first-in-human trial for ALK-positive lung cancer is now recruiting near Perth, Australia. Other sites for the FORGE-1 trial will be added in Australia and the U.S. over the next few months. Initially, a small number of people will be given this ALK inhibitor to ascertain safety and dosing. More patients will be then recruited to prove effectiveness. The ideal candidate for this trial has progressed on a TKI and is at a juncture in treatment. This is an exciting study that could lead to a new standard of care for those with ALK-positive lung cancer. To learn more, click here.

Clinical trials play an important role in the long-term survival of many lung cancer patients. Below is a compilation of resources that will help ALK-positive patients and their care teams identify suitable clinical trials that are open to them.

COVID-19 & CLINICAL TRIALS

Despite the pandemic, several new trials for ALK lung cancer are recruiting for patients. Because of Covid-19, the trial teams are finding safe ways to treat participants (telemedicine, mailing meds to home, etc).

ALK LUNG CANCER CLINICAL TRIAL HELP AND SEARCHING

ALK Positive Support Group Clinical Trials Spreadsheet*

GO2 Foundation for Lung Cancer - LUNGMATCH

LUNGevity Online Clinical Trial Finder

CenterWatch Clinical Trials Search

MassiveBio Clinical Trials Search

General Info about ALK NSCLC Clinical Trials

As of May 2021, there are at least 45 clinical trials that are recruiting specifically for people with ALK-positive lung cancer. Many of these trials have multiple sites worldwide. Since ALK-positive lung cancer is a rare disease, it is difficult for any one oncologist to be aware of all the trials available. You can advocate for yourself and find a clinical trial that may be a good fit for you at any juncture in treatment.

*Spreadsheet developed by ALK Positive Volunteer Ellee Urban and ALK Positive MPAC in August 2018. Updated monthly and posted in the ALK Positive Support Group.

Disclaimer: these trials have been consolidated by a volunteer and should not be considered exhaustive. Listing of these trials is not an endorsement, and ALK Positive does not recommend one trial over another. Please talk with your doctor about these or any trials you are interested in.

Author: Ellee Urban

Update on Clinical Trials Currently Recruiting for ALK-positive Lung Cancer